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产品目录

PKR/EIF2AK2抗体图片
产品货号:
Z24065
中文名称:
PKR/EIF2AK2抗体
英文名称:
Anti-PKR/EIF2AK2 Antibody
产品规格:
0.1mg
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-PKR/EIF2AK2 Antibody
指标别名eIF 2A protein kinase 2;EIF2AK1;EIF2AK2;P1/eIF 2A protein kinase;p68 kinase;PKR;PRKR;Protein kinase RNA activated
克隆性Polyclonal
检验物种human,mouse,rat
应用范围ELISA,WB,IHC,IF
基因名称EIF2AK2
抗体来源Rabbit
抗体类型IgG
免疫原Anti-PKR antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human PKR.The immunogen is located within the last 50 amino acids of PKR.
计算分子量62kDa
成分PKR Antibody is supplied in PBS containing 0.02% sodium azide.
纯化方式PKR Antibody is affinity chromatography purified via peptide column.
浓度1mg/mL
产品形态溶液
保存条件4℃可保存3个月,-20℃可保存1年。
背景资料The interferon-inducible,double-stranded RNA (dsRNA)-dependent protein kinase PKR is a member of the eukaryotic initiation factor-2 alpha (eIF2-alpha) kinase family,possessing serine-threonine kinase activity and two dsRNA-binding motifs that acts as part of the innate immune system.Upon binding dsRNA,PKR undergoes a conformational change leading to its activation and its phosphorylation of the translation factor eIF2,resulting in a general shutdown of protein synthesis and induction of apoptosis through upregulation of caspase-8 and capsase-9 activity in order to prevent the production of more viruses.To evade the antiviral effects of PKR,viruses have evolved multiple mechanisms,such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus.More recently,PKR has been implicated in several neurodegenerative diseases including Alzheimer,Huntington,and amyotrophic lateral sclerosis.
Uniprot IDP19525
基因名全称Eukaryotic translation initiation factor 2-alpha kinase 2
蛋白名全称Eukaryotic translation initiation factor 2-alpha kinase 2
推荐稀释比WB:1μg/mL;IF:20μg/mL;IHC:2.5~5μg/mL.Antibody validated:Western Blot in human and mouse samples;Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse samples.All other applications and species not yet tested.

相关搜索:PKR/EIF2AK2抗体PKR抗体EIF2AK2多抗Anti-PKR/EIF2AK2 Antibody
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